Ongoing projects

Study SWITCH-BD: Sleep-wake patterns in the change of mood in bipolar disorder.
Investigators Prof. dr. R.A. Schoevers, dr. R.F. Riemersma-van der Lek, S.E. Knapen, MSc
Date September 2016 – November 2017
Purpose The SWITCH-BD study aims to unravel the relationship between circadian rhythm disturbances, sleep problems and the development of mood episodes in patients with bipolar disorder.
Participants Patients with bipolar disorder type I
Study Experience sampling feedback in the diagnosis of first psychosis
Investigators Drs. F.M. Bos, Dr. W.A. Veling, Dr. E. Snippe, Dr. J.A.J. van der Krieke, Prof. Dr. M.C. Wichers, Dr. R. Bruggeman
Date Sept 2017 onwards
Purpose To investigate the application of experience sampling methodology (ESM) feedback to the diagnosis of patients with first psychosis. We will evaluate 1) what insights ESM feedback offers patients and clinicians, and 2) in what way ESM feedback influences ensuing treatment.
Participants 20 patients with first psychosis
Study TRAILS TRANS-ID: Tracking transition across diagnostic boundaries of psychopathology
Investigators Prof. Dr. Marieke Wichers, Dr. Catharina Hartman, Dr. Hanneke Wigman, Drs. Robin Groen, Drs. Marieke Schreuder
Date Sept 2017 – April 2021
Purpose The TRAILS TRANS-ID project investigates whether personalized early warning signals and network characteristics are informative for the type of symptoms individuals may develop.
Participants Participants are individuals from the TRAILS-CC sample
Study TRANS-ID tapering: Transitions In Depressive symptoms during tapering of antidepressants
Investigators Prof. Marieke Wichers, Dr. Evelien Snippe, Dr. Harriette Riese, Drs. Arnout Smit, Drs. Yoram Kunkels
Date May 2017 – Sept 2020
Purpose The TRANS-ID Tapering project investigates whether early warning signals precede critical transitions in depressive symptoms within single individuals during or after tapering of antidepressants.
Participants Participants are adults (age ≥ 18) with a history of depression who made a shared decision with their medical doctor to taper their antidepressant medication.
Study TRANS-ID recovery: Monitoring mood during psychological treatment
Investigators Prof. Marieke Wichers, Dr. Evelien Snippe, Dr. Harriette Riese, Drs. Marieke Helmich, Drs. Yoram Kunkels
Date May 2017 – Nov 2020
Purpose The TRANS-ID Recovery project investigates whether the moment individuals begin to recover from depressive symptoms is anticipated by personalized early warning signals.
Participants Participants are adults (age ≥ 18) with current depressive symptoms who are due to start a psychological treatment for depressive symptoms.
Study Patient-specific measurement of (functional) movement disorders
Investigators Drs. G. Kramer, Prof. dr. M.A.J. De Koning-Tijssen, Prof. Dr. J.G.M. Rosmalen
Date July 2016 till December 2017
Purpose To determine contributing factors to symptom fluctuation in (functional) movement disorders
Participants Participants with a neurological movement disorder and participants with a functional movement disorders
Study A guided peer support intervention to improve social support and life skills in patients with a psychotic disorder
Investigators MSc. J.S Vogel, Prof. dr. P.F. Roodbol,Prof. dr. Mark van der Gaag, Dr. S. Castelein, Dr. J. Bruins
Date 2016 – Dec 2019
Purpose Decline in loneliness in people with psyhotic disorders
Participants Individuals with a psychotic disorder living in the community (n=4×25)
Study ZELF-i Self-monitoring and personalized feedback as a tool to boost depression treatment
Investigators Dr. J.A.C.J. Bastiaansen, Prof. dr. A.J. Oldehinkel
Date June 2016 – June 2018
Purpose To investigate the effectiveness of selfmonitoring and personalized feedback as a stepping stone for the treatment of depressive complaints.
Participants 150 depressed outpatients between 18 and 65 years of age attending mental health care organizations in the North of the Netherlands
Study Mapping Individual Routes of Risk and Resilience (MIRORR) study
Investigators Dr. J.T.W. Wigman, Dr. S.H. Booij, Prof. dr. M.C.Wichers, Prof. dr. L.Wunderink
Date March 2016 onwards
Purpose To predict the onset and progression of psychopathology, in particular psychosis, by means of dynamic symptomnetworks
Participants Four subgroups of increasing risk for psychosis (n=4×25)
Study Experience sampling in patients with bipolar disorder
Investigators Drs. F.M. Bos, Dr. E. Snippe, Dr J.A.J. van der Krieke, Prof. Dr. M.C. Wichers, Dr. R. Bruggeman, dr. B. Doornbos
Date April 2016 onwards
Purpose To investigate the application of experience sampling methodology (ESM) to clinical practice in patients with bipolar disorder. We will investigate whether transitions to a depressed or manic state can be predicted by using ESM data. Next, we will evaluate whether clinicians and patients find the ESM procedure and feedback a valuable addition to standard care.
Participants 20 patients with bipolar disorder (rapid cycling)
Study Dagboekstudie Yogagroep CIP
Investigators Nina Volbehr, Dr. Sanne Booij, Dr. Agna Bartels-Veldhuis
Date January 2016 onwards
Purpose To better understand whether a yoga training influences psychiatric symptoms and underlying mechanisms.
Participants 13 clients of the Centrum Integrale Psychiatrie (Lentis) participating in a 9-week yoga training
Study HoeGekIsNL Diary study Mood and Anxiety in Daily life (MAD)
Investigators Dr. E.H. Bos, Prof. Dr. P. de Jonge, Dr. J.A.J. van der Krieke, Dr. B.F. Jeronimus, MSc, H.M. Schenk, MD, F.J. Blaauw, MSc, Dr. K.J. Wardenaar, S. de Vos, MSc, R.B.K. Wanders, MSc, Dr. J.T.W. Wigman
Date June 2014 onwards
Purpose To investigate the temporal dynamics of mood and anxiety symptoms, and factors associated with these symptoms within individuals. To examine to what extent these patterns are person-specific or generic.
Participants 200 (general population)
Study NESDA diary study
Investigators Dr H. Riese, Prof Dr R.A. Schoevers, Dr F. Lamers, Dr L. Boschloo, Prof Dr P. de Jonge
Date 2014 onwards
Purpose The main aim of this study is to provide new insights into the nature of daily mood fluctuations that can explain the differences in severity and nature of mood disorder beyond the traditional DSM classifications.
Participants 400 patients with mood disorders, their sibs and healthy controls
Study Idiographic study of Cognitive function, Affect, and Sleep in Early Alzheimer (i-CASE)
Investigators Dr. Marij Zuidersma, Prof. Richard Oude Voshaar
Date February 2014 onwards
Purpose 1) Evaluate the temporal dynamics between sleep disturbances, depression and cognitive function within elderly individuals with cognitive impairments and depression.2) Evaluate whether other (time-varying and time-stable) variables, such as the circadian rhythm, the presence of somatic diseases and physical activity affect the temporal relationship between sleep disturbances, depression and cognitive function within the individual3) Evaluate whether giving feedback on personal triggers for cognitive impairments, depression and sleep disturbances to patients gives insight to these patients and is helpful for them
Participants 20 Patients with mild cognitive impairments of mild dementia due to Alzheimer’s disease, and with depression (according to MINI or GDS>=4).
Study TRENSS 2
Investigators Drs. C. Kos, Prof. Dr. A. Aleman
Date September 2012- April 2018
Purpose The main objective is to investigate whether treatment using neurostimulation (tDCS or rTMS) targeting the rDLPFC reduces apathy in schizophrenia patients by activating the targeted brain region and whether tDCS is equally effective as rTMS. A secondary aim is to evaluate if a psychosocial intervention, in the form of BAT, in addition to a biological intervention, TMS, further reduces the level of apathy.
Participants 125 schizophrenia patients