Ongoing projects

Study MINDCOG: mechanisms of change of short therapeutic interventions to reduce perseverative cognition—a vulnerability for depression.
Investigators M.E. Besten, MSc, dr. M.J. van Tol, dr. M.K. van Vugt, prof. dr. A. Aleman, dr. H. Riese
Date October 2019 onwards
Purpose To investigate 1) the psycho-physiological and cognitive mechanisms by which one-week App-based training of fantasizing vs. mindfulness affect perseverative cognitions (PC) and 2) if pre-therapeutic individual characteristics predict superior effectivity of one intervention over the other in reducing perseverative cognitions (PC).
Participants 50 remitted Major Depressive Disorder patients and 50 health controls. Exclusion criteria: psychotic symptoms, manic symptoms, comorbid epilepsy, the use of tricyclic antidepressants.
Study MATCH: Modifying psychologicAl Treatment to the CHaracteristics and needs of cancer survivors
Investigators Prof. dr. Hans Knoop, dr. Annemarie Braamse & Susan Harnas, MSc (onderzoeksteam Amsterdam UMC, locatie AMC), prof dr. Judith Rosmalen (UMCG, ICPE)
Date 1 July 2018 untill 30 June 2022
Purpose To examine whether personalized psychological treatment has added value to protocolled psychological treatment on patient functioning in cancer survivors
Participants 186 cancer survivors with severe cancer-related fatigue, depression and/or fear of cancer recurrence. More specific, patients after esophageal, hematological malignancy treated with allogeneic stem cell transplantation, and patients after breast cancer are included in this study. Exclusion criteria: psychotic symptoms, manic symptoms, comorbid epilepsy, the use of tricyclic antidepressants.
Study Chronotherapy
Investigators Drs. S.J.M. Druiven, Dr. B.C.M. Haarman, Dr. H. Riese, Dr. J. Kamphuis, Dr. Y. Meesters, Prof. Dr. R.A. Schoevers
Date 1 October 2018
Purpose To examine predictors of positive response to chronotherapy as treatment of a depressive episode
Participants 50 patients diagnosed with a depressive episode in the context of a depressive disorder or bipolar disorder. Exclusion criteria: psychotic symptoms, manic symptoms, comorbid epilepsy, the use of tricyclic antidepressants.
Study Therap-i: Personalized self-monitoring and feedback tool to improve standard treatment of affective disorders.
Investigators Dr. H. Riese, Drs. D.C. van der Veen, Dr. M.N. Servaas, Drs. P.L. von Klipstein, Prof. Dr. R.A. Schoevers
Date January 2018 – December 2021
Purpose To investigate the use of personalized self-monitoring and feedback as a tool for collaborative case-conceptualization in the treatment of patient experiencing complex affective disorders.
Participants 100 depressed outpatients between 18 and 65 years of age that exhibit some form of complexity
Study Experience sampling feedback in the diagnosis of first psychosis
Investigators Drs. F.M. Bos, Dr. W.A. Veling, Dr. E. Snippe, Dr. J.A.J. van der Krieke, Prof. Dr. M.C. Wichers, Dr. R. Bruggeman
Date Sept 2017 onwards
Purpose To investigate the application of experience sampling methodology (ESM) feedback to the diagnosis of patients with first psychosis. We will evaluate 1) what insights ESM feedback offers patients and clinicians, and 2) in what way ESM feedback influences ensuing treatment.
Participants 20 patients with first psychosis
Study Handling Antipsychotic Medication, Long- term Evaluation of Targeted Treatment (HAMLETT)
Investigators Drs. Iris Sommer, Wim Veling, Marieke Begemann, Erna van ’t Hag, Chris Geraets, Ilse Thompson, Alban Voppel, Priscilla Oomen
Date Sept 2017 – Sept 2024
Purpose The current guidelines advise to continue antipsychotic use at least for 1 year after remission of the complaints. However, early tapering of antipsychotics may be beneficial for functioning. The HAMLETT study examines whether following the current guidelines, or whether early tapering of antipsychotics is most beneficial for long-term functioning.
Participants Patients with a first psychosis that use antipsychotics.
Study TRAILS TRANS-ID: Tracking transition across diagnostic boundaries of psychopathology
Investigators Prof. Dr. Marieke Wichers, Dr. Catharina Hartman, Dr. Hanneke Wigman, Drs. Robin Groen, Drs. Marieke Schreuder
Date Sept 2017 – April 2021
Purpose The TRAILS TRANS-ID project investigates whether personalized early warning signals and network characteristics are informative for the type of symptoms individuals may develop.
Participants Participants are individuals from the TRAILS-CC sample
Study TRANS-ID tapering: Transitions In Depressive symptoms during tapering of antidepressants
Investigators Prof. Marieke Wichers, Dr. Evelien Snippe, Dr. Harriette Riese, Drs. Arnout Smit, Drs. Yoram Kunkels
Date May 2017 – Sept 2020
Purpose The TRANS-ID Tapering project investigates whether early warning signals precede critical transitions in depressive symptoms within single individuals during or after tapering of antidepressants.
Participants Participants are adults (age ≥ 18) with a history of depression who made a shared decision with their medical doctor to taper their antidepressant medication.
Study TRANS-ID recovery: Monitoring mood during psychological treatment
Investigators Prof. Marieke Wichers, Dr. Evelien Snippe, Dr. Harriette Riese, Drs. Marieke Helmich, Drs. Yoram Kunkels
Date May 2017 – Nov 2020
Purpose The TRANS-ID Recovery project investigates whether the moment individuals begin to recover from depressive symptoms is anticipated by personalized early warning signals.
Participants Participants are adults (age ≥ 18) with current depressive symptoms who are due to start a psychological treatment for depressive symptoms.
Study Patient-specific measurement of (functional) movement disorders
Investigators Drs. G. Kramer, Prof. dr. M.A.J. De Koning-Tijssen, Prof. Dr. J.G.M. Rosmalen
Date July 2016 onwards
Purpose To determine contributing factors to symptom fluctuation in (functional) movement disorders
Participants Participants with a neurological movement disorder and participants with a functional movement disorders
Study A guided peer support intervention to improve social support and life skills in patients with a psychotic disorder
Investigators MSc. J.S Vogel, Prof. dr. P.F. Roodbol,Prof. dr. Mark van der Gaag, Dr. S. Castelein, Dr. J. Bruins
Date 2016 – Dec 2019
Purpose Decline in loneliness in people with psyhotic disorders
Participants Individuals with a psychotic disorder living in the community (n=4×25)
Study ZELF-i Self-monitoring and personalized feedback as a tool to boost depression treatment
Investigators Dr. J.A.C.J. Bastiaansen, Prof. dr. A.J. Oldehinkel
Date June 2016 – June 2019
Purpose To investigate the effectiveness of selfmonitoring and personalized feedback as a stepping stone for the treatment of depressive complaints.
Participants 150 depressed outpatients between 18 and 65 years of age attending mental health care organizations in the North of the Netherlands
Study Mapping Individual Routes of Risk and Resilience (MIRORR) study
Investigators Dr. J.T.W. Wigman, Dr. S.H. Booij, Prof. dr. M.C.Wichers, Prof. dr. L.Wunderink
Date March 2016 onwards
Purpose To predict the onset and progression of psychopathology, in particular psychosis, by means of dynamic symptomnetworks
Participants Four subgroups of increasing risk for psychosis (n=4×25)
Study Experience sampling in patients with bipolar disorder
Investigators Drs. F.M. Bos, Dr. E. Snippe, Dr J.A.J. van der Krieke, Prof. Dr. M.C. Wichers, Dr. R. Bruggeman, dr. B. Doornbos
Date April 2016 onwards
Purpose To investigate the application of experience sampling methodology (ESM) to clinical practice in patients with bipolar disorder. We will investigate whether transitions to a depressed or manic state can be predicted by using ESM data. Next, we will evaluate whether clinicians and patients find the ESM procedure and feedback a valuable addition to standard care.
Participants 20 patients with bipolar disorder (rapid cycling)
Study Dagboekstudie Yogagroep CIP
Investigators Nina Volbehr, Dr. Sanne Booij, Dr. Agna Bartels-Veldhuis
Date January 2016 onwards
Purpose To better understand whether a yoga training influences psychiatric symptoms and underlying mechanisms.
Participants 13 clients of the Centrum Integrale Psychiatrie (Lentis) participating in a 9-week yoga training
Study TRAILS – tracking the next generation
Investigators Dr. C.A. Hartman, Dr. A.M. Sluiter-Oerlemans, Dr. J.S. Klop-Richards, Drs. S.A. Barzeva, Dr. T. Kretschmer, Dr. C. Vrijen, Drs. H.W. Ozinga
Date February 2015 onwards
Purpose To study parent and child development as early as possible and investigate how parental characteristics influence the development of their children.
Participants TRAILS Participants who are or will become parents in the upcoming years.
Study HoeGekIsNL Diary study Mood and Anxiety in Daily life (MAD)
Investigators Dr. E.H. Bos, Prof. Dr. P. de Jonge, Dr. J.A.J. van der Krieke, Dr. B.F. Jeronimus, MSc, H.M. Schenk, MD, F.J. Blaauw, MSc, Dr. K.J. Wardenaar, S. de Vos, MSc, R.B.K. Wanders, MSc, Dr. J.T.W. Wigman
Date June 2014 onwards
Purpose To investigate the temporal dynamics of mood and anxiety symptoms, and factors associated with these symptoms within individuals. To examine to what extent these patterns are person-specific or generic.
Participants 200 (general population)
Study Idiographic study of Cognitive function, Affect, and Sleep in Early Alzheimer (i-CASE)
Investigators Dr. Marij Zuidersma, Prof. Richard Oude Voshaar
Date February 2014 onwards
Purpose 1) Evaluate the temporal dynamics between sleep disturbances, depression and cognitive function within elderly individuals with cognitive impairments and depression.2) Evaluate whether other (time-varying and time-stable) variables, such as the circadian rhythm, the presence of somatic diseases and physical activity affect the temporal relationship between sleep disturbances, depression and cognitive function within the individual3) Evaluate whether giving feedback on personal triggers for cognitive impairments, depression and sleep disturbances to patients gives insight to these patients and is helpful for them
Participants 20 Patients with mild cognitive impairments of mild dementia due to Alzheimer’s disease, and with depression (according to MINI or GDS>=4).