Finished projects

Study TRENSS 2
Investigators Drs. C. Kos, Prof. Dr. A. Aleman
Date September 2012- May 2018
Purpose The main objective is to investigate whether treatment using neurostimulation (tDCS or rTMS) targeting the rDLPFC reduces apathy in schizophrenia patients by activating the targeted brain region and whether tDCS is equally effective as rTMS. A secondary aim is to evaluate if a psychosocial intervention, in the form of BAT, in addition to a biological intervention, TMS, further reduces the level of apathy.
Participants 125 schizophrenia patients
Study NESDA diary study
Investigators Dr H. Riese, Prof Dr R.A. Schoevers, Dr F. Lamers, Dr L. Boschloo, Prof Dr P. de Jonge
Date 2014 – 2017
Purpose The main aim of this study is to provide new insights into the nature of daily mood fluctuations that can explain the differences in severity and nature of mood disorder beyond the traditional DSM classifications.
Participants 400 patients with mood disorders, their sibs and healthy controls
Study Sleep and agitation in nursing home patients with dementia
Investigators Prof. Dr. S.U. Zuidema, Drs. R. Wijbenga, Dr. M. Zuidersma
Date February 2017- July 2017
Purpose The aim is to investigate the temporal association between sleep and agitation in nursing home residents with dementia. Do temporal associations between sleep and agitation differ between individuals? And what is the feasibility of evaluating sleep and agitation with actigraphy for 2 months in dementia patients?
Participants 5 nursing home residents with dementia
Study SWITCH-BD: Sleep-wake patterns in the change of mood in bipolar disorder.
Investigators Prof. dr. R.A. Schoevers, dr. R.F. Riemersma-van der Lek, S.E. Knapen, MSc
Date September 2016 – November 2017
Purpose The SWITCH-BD study aims to unravel the relationship between circadian rhythm disturbances, sleep problems and the development of mood episodes in patients with bipolar disorder.
Participants Patients with bipolar disorder type I
Study Pilot TRANS-ID tapering: transitions in depressive symptoms during tapering of antidepressants
Investigators Prof. M. Wichers & Dr. E. Snippe
Date Nov 2015 – Jan 2017
Purpose The aim of this pilot study is to examine (1) whether monitoring of daily experiences during and after tapering of antidepressants gives personalized insights in warning signals preceding transitions in depression (2) whether individuals find it helpful to monitor their daily experiences during and after tapering of depressive symptoms. Furthermore, the feasibility of this intensive diary study will be examined and the diary questions included in the study will be evaluated with participants. This is a pilot for the larger TRANS-ID tapering study.
Participants Participants should meet all of the following criteria: – age ≥ 18 – a history of depressive symptoms – having made a shared decision with a mental health care provider to taper the current dose of antidepressant medication – having made a tapering scheme or plan with a mental health care provider
Study The effect of Virtual Reality exposure Therapy (VRET) on social participation in people with a psychotic disorder: a multisite randomised controlled trial
Investigators Chris Geraets, msc Drs. Roos Pot-Kolder (VU) Dr. Wim Veling Prof. Dr. Mark vd Gaag
Date Nov 2014 – Dec 2015
Purpose First, to investigate the effect of Virtual Reality exposure therapy on social participation. Second, to investigate the longitudinal course of symptoms and social behaviour in psychosis on group and individual level.
Participants 100 patients with psychotic disorder
Study Blues Clues
Investigators Dr. M. aan het Rot, K. Hogenelst, M.Sc., Prof. Dr. R.A. Schoevers
Date April 2012 – August 2014
Purpose To investigate the role of serotonin in mood and interactions with others
Participants 60 individuals with a family history of depression
Study Trichotillomanics
Investigators S.D.M. van Dijk, Dr. E.H. Bos
Date February 2012
Purpose To investigate the usefulness of the Psymate as an intervention tool in Trichotillomanics
Participants 1 patient with trichotillomanics
Study No Fun No Glory
Investigators Prof. Tineke Oldehinkel, Dr. Eeske van Roekel, Dr. Charlotte Vrijen, Drs. Vera Heininga, Drs. Maurits Masselink
Date 2015-2016
Purpose This exploratory intervention study is set out to examine effects of tailor-made lifestyle advice, based on observed individual temporal patterns of lifestyle factors and experienced pleasure, as a non-pharmacological means to restore the pleasure of everyday activities and accomplishments. In addition, we will explore whether exposure to tandem skydiving, an experience known to activate the dopamine system and to elicit strong emotions, can help to reboot the reward system and hence foster the recommended lifestyle changes.
Participants N = 69 anhedonic participants, N = 69 healthy controls
Study Stress hormone dynamics in healthy individuals
Investigators S.L. van Ockenburg, MD, Prof. Dr. J.G.M Rosmalen
Date July 2012-March 2013
Purpose The objective of this study is to investigate the within-person dynamics of psychosocial stress levels and its effect on subsequent day-to-day fluctuations in blood pressure, heart rate, cortisol and melatonin levels in healthy volunteers for a period of 63 consecutive days by means of multivariate time-series analyses.
Participants 10 healthy volunteers
Study Uncovering the Positive Potential of Emotional Reactivity (UPPER): A combined diary-neuroimaging approach
Investigators Dr. J.A.C.J. Bastiaansen, Drs. E.C. Bennik, Prof. dr. A.J. Oldehinkel, Prof. dr. J. Ormel
NIC: Prof. Dr. A. Aleman and Dr. J.B.C. Marsman
Date June 2012 –December 2013
Purpose The proposed study aims to investigate whether (part of the) individuals who are at high risk to develop affective problems when faced with adversities also benefit more from positive environmental influences. Its main objective is to investigate how emotional reactivity to negative experiences and emotional reactivity to positive experiences are related in daily life and in the brain.
Participants 75 healthy students
Study Mood and Movement in Daily life (MOOVD)
Investigators S.H. Booij, MSc, M.E.J. Bouwmans, MSc, Dr. E.H. Bos, Prof. dr. P. de Jonge, Prof. dr. A.J. Oldehinkel
Date 2012 – June 2014
Purpose The primary aim of this study is to investigate the role of physical activity in the etiology of depressed mood, individual differences therein, and clues for tailor-made interventions. A second aim of this study is to elucidate the temporal relationship between mood symptoms and several stress-related hormones and enzymes, such as cortisol and alpha-amylase.
Participants 60 (30 depressed individuals, 30 non-depressed individuals)
Study Fluctuations in Agoraphobia
Investigators S.A. Nijdam, BSc, Dr. H. Riese, Prof. Dr. R.A. Schoevers
Date Oct 2012 – Mar 2013
Purpose Investigating the bidirectional association between heart rate variability (HRV) and anxiety symptoms to get a better understanding of the individual etiology of patients with panic disorder combined with agoraphobia.
Participants 3 patients with agoraphobia